## Abstract Among mutations associated with autosomal dominant and sporadic Parkinson's disease (PD) the G2019S substitution in the leucine‐rich repeat kinase 2 (LRRK2) gene is the most frequently identified. To estimate its frequency in Russia, we analyzed 208 patients with PD from the Northwester
LRRK2 G6055A mutation in Italian patients with familial or sporadic Parkinson’s disease
✍ Scribed by D Civitelli; P Tarantino; G Nicoletti; IC Cirò Candiano; F Annesi; EV De Marco; S Carrideo; FE Rocca; F Condino; P Spadafora; P Pugliese; S D’Asero; M Morelli; S Paglionico; G Annesi; A Quattrone
- Book ID
- 110888367
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 80 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0009-9163
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To evaluate the frequency of the LRRK2 G2019S mutation in Italy, we tested 1,072 probands with Parkinson's disease (PD; 822 sporadic and 250 familial): 20 patients (1.9%) carried the G2019S mutation, 11 patients (1.3%) were sporadic, and 9 (4.3%) had a positive family history. Considering only proba
## Abstract Mutations in the __Leucine‐Rich Repeat Kinase 2__ (__LRRK2__) gene are the most frequent known cause of Parkinson's disease (PD), but their prevalence varies markedly between populations. Here we studied the frequency and associated phenotype of four recurrent __LRRK2__ mutations (R1441
## Abstract Mutations in the leucine‐rich repeat kinase 2 (__LRRK2__) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine‐to‐serine amino acid substitution at cod