LRRK2: bridging the gap between sporadic and hereditary Parkinson's disease
β Scribed by Alexis Elbaz
- Book ID
- 114408940
- Publisher
- The Lancet
- Year
- 2008
- Tongue
- English
- Weight
- 105 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1474-4465
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## Abstract Among mutations associated with autosomal dominant and sporadic Parkinson's disease (PD) the G2019S substitution in the leucineβrich repeat kinase 2 (LRRK2) gene is the most frequently identified. To estimate its frequency in Russia, we analyzed 208 patients with PD from the Northwester
## Abstract Mutations in the __LeucineβRich Repeat Kinase 2__ (__LRRK2__) gene are the most frequent known cause of Parkinson's disease (PD), but their prevalence varies markedly between populations. Here we studied the frequency and associated phenotype of four recurrent __LRRK2__ mutations (R1441