LRP5 functions in bone to produce high bone mass phenotypes
β Scribed by M.L. Warman
- Book ID
- 116324195
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 58 KB
- Volume
- 48
- Category
- Article
- ISSN
- 8756-3282
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## Abstract Patients with an activation mutation of the __Lrp5__ gene exhibit high bone mass (HBM). Limited information is available regarding compartmentβspecific changes in bone. The relationship between the phenotype and serum serotonin is not well documented. To evaluate bone, serotonin, and bo
## Abstract The __Lrp5__ gene is a major determinant of bone mass accrual. It has been demonstrated recently to achieve this function by hampering the synthesis of gutβderived serotonin, which is a powerful inhibitor of bone formation. In this study we analyzed plasma serotonin levels in patients w