Gsα overexpression and loss of Gsα impri
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Christophe Picard; Monique Silvy; Corinne Gerard; Christophe Buffat; Esteban Lav
📂
Article
📅
2007
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John Wiley and Sons
🌐
French
⚖ 335 KB
## Abstract Gsα, the α‐subunit of the heterotrimeric GTP‐binding protein, is coded from the __GNAS__ gene, which is imprinted in a tissue‐specific manner. Gsα is paternally silenced in normal pituitary, but Gsα imprinting relaxation is found in some tumoral tissue. In addition, Gsα mRNA levels are