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Activating Mutations of Gsα in Kidney Cancer

✍ Scribed by Kalfa, Nicolas; Lumbroso, Serge; Boulle, Nathalie; Guiter, Jacques; Soustelle, Laurent; Costa, Pierre; Chapuis, Heliette; Baldet, Pierre; Sultan, Charles


Book ID
121985876
Publisher
Lippincott Williams and Wilkins
Year
2006
Tongue
English
Weight
336 KB
Volume
176
Category
Article
ISSN
0022-5347

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Activating mutations of Gs protein in mo
✍ Benjamin A. Alman; Debra A. Greel; Hubert J. Wolfe 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 626 KB

## Abstract Activating mutations of the alpha chain of the heterotrimeric signal transducer Gs disrupt the inherent guanosine triphosphatase activity of the alpha chain, stimulate adenylyl cyclase, and can result in independent cell proliferation. Such mutations are identified in a number of endocr