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Distribution of Gs-α activating mutations in human thyroid tumors measured by subcloning

✍ Scribed by Victor N. Gorelov; Marianna Gyenes; Frank Neser; Hans-Dieter Röher; Peter E. Goretzki


Book ID
112494675
Publisher
Springer-Verlag
Year
1996
Tongue
English
Weight
580 KB
Volume
122
Category
Article
ISSN
1432-1335

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Rare mutations of the Gs alpha subunit g
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Background. The Gs alpha (Gsa) gene can be activated to the putative oncogene gsp by specific point mutations at codons 201 or 227. Such mutations have been reported in growth hormone (GH)-secreting pituitary adenomas and thyroid tumors. To clarify the role of Gsa gene in human endocrine tumors, 197