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Overexpression of Gsα subunit in thyroid tumors bearing a mutated Gsα gene

✍ Scribed by Victor N. Gorelov; Kristoffel Dumon; Natalie S. Barteneva; Dieter Palm; Hans-Dieter Röher; Peter E. Goretzki

Book ID
112527455
Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
766 KB
Volume
121
Category
Article
ISSN
1432-1335

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✍ Christophe Picard; Monique Silvy; Corinne Gerard; Christophe Buffat; Esteban Lav 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 335 KB

## Abstract Gsα, the α‐subunit of the heterotrimeric GTP‐binding protein, is coded from the __GNAS__ gene, which is imprinted in a tissue‐specific manner. Gsα is paternally silenced in normal pituitary, but Gsα imprinting relaxation is found in some tumoral tissue. In addition, Gsα mRNA levels are