Activating mutations in the NH2- and COO
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Sunil K. Gupta; N. Dhanasekaran; Lynn E. Heasley; Gary L. Johnson
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Article
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1991
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John Wiley and Sons
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English
⚖ 834 KB
The a subunit polypeptides of the G proteins G, and G,, stimulate and inhibit adenylyl cyclase, respectively. The a, and a,, subunits are 65% homologous in amino acid sequence but have highly conserved GDP/GTP binding domains. Previously, we mapped the functional adenylyl cyclase activation domain t