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GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

✍ Scribed by Landis, Claudia A.; Masters, Susan B.; Spada, Anna; Pace, Ann M.; Bourne, Henry R.; Vallar, Lucia


Book ID
109760923
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
604 KB
Volume
340
Category
Article
ISSN
0028-0836

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The a subunit polypeptides of the G proteins G, and G,, stimulate and inhibit adenylyl cyclase, respectively. The a, and a,, subunits are 65% homologous in amino acid sequence but have highly conserved GDP/GTP binding domains. Previously, we mapped the functional adenylyl cyclase activation domain t