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Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas

✍ Scribed by Marina N Nikiforova; Raffaele Ciampi; Giuliana Salvatore; Massimo Santoro; Manoj Gandhi; Jeffrey A Knauf; Gerry A Thomas; Stephen Jeremiah; Tatyana I Bogdanova; Mykola D Tronko; James A Fagin; Yuri E Nikiforov

Book ID: 116333008
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 198 KB
Volume: 209
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2003.12.004

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## Abstract In papillary thyroid carcinogenesis, the constitutively activated mitogen‐activated protein (MAP) kinase signaling pathway caused by a genetic alteration such as __RET__/__PTC__ rearrangement or mutation of __RAS__ and __BRAF__ genes, is thought to be a major early event. Among these, t