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Low plasma level of all-trans retinoic acid after feeding tube administration for acute promyelocytic leukemia

✍ Scribed by Kimitaka Takitani; Yoshitaka Nakao; Yoshiyuki Kosaka; Akiko Inoue; Chihiro Kawakami; Tomoko Kuno; Hiroshi Tamai


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
185 KB
Volume
76
Category
Article
ISSN
0361-8609

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## Abstract The use of arsenic trioxide (As~2~O~3~, ATO) combined with all‐trans retinoic acid (ATRA) has recently been reported to induce remission in patients with acute promyelocytic leukemia (APL). However, its efficiency remains inconclusive mainly due to the small number of the available case

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A 22-year-old female presented with acute promyelocytic leukemia (APL). Treatment with all-trans retinoic acid (ATRA) resulted in a severe exacerbation of the coagulopathy 5 days after its introduction. This was complicated by bone marrow necrosis, parenchymal liver damage and acute tubular necrosis