A 22-year-old female presented with acute promyelocytic leukemia (APL). Treatment with all-trans retinoic acid (ATRA) resulted in a severe exacerbation of the coagulopathy 5 days after its introduction. This was complicated by bone marrow necrosis, parenchymal liver damage and acute tubular necrosis
โฆ LIBER โฆ
Reversible cardiac dysfunction without myocytolysis related to all-trans retinoic acid administration during induction therapy of acute promyelocytic leukemia
โ Scribed by Annunziata Manna; Luigi Cadenotti; Andrea Motto; Piercarlo Ballo
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 52 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0939-5555
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Background. Differentiation therapy with all-trans retinoic acid (RA) induces more than 80% complete remission with the least complications in patients with acute promyelocytic leukemia (APL). The authors studied the cost-benefit of this new treatment modality compared with conventional chemotherapy