Low frequency of common LRRK2 mutations in Mexican patients with Parkinson's disease
✍ Scribed by Petra Yescas; Marisol López; Nancy Monroy; Marie-Catherine Boll; Mayela Rodríguez-Violante; Ulises Rodríguez; Adriana Ochoa; María Elisa Alonso
- Book ID
- 116772557
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 191 KB
- Volume
- 485
- Category
- Article
- ISSN
- 0304-3940
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To evaluate the frequency of the LRRK2 G2019S mutation in Italy, we tested 1,072 probands with Parkinson's disease (PD; 822 sporadic and 250 familial): 20 patients (1.9%) carried the G2019S mutation, 11 patients (1.3%) were sporadic, and 9 (4.3%) had a positive family history. Considering only proba
## Abstract The G2019S mutation in the __LRRK2__ gene is reportedly a common cause of familial Parkinson's disease (PD) and may also have a significant role in nonfamilial PD. The objective of this study was to assess mutation carrier frequency in PD patients from movement disorder clinics in the U