Genetic analysis of LRRK2 mutations in patients with Parkinson disease
β Scribed by Hao Deng; WeiDong Le; Yi Guo; Christine B. Hunter; WenJie Xie; MaoSheng Huang; Joseph Jankovic
- Book ID
- 119302112
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 237 KB
- Volume
- 251
- Category
- Article
- ISSN
- 0022-510X
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genes and who were found to be negative. 1 In this group of 122 patients, we identified 5 patients with an FMR1 premutation and in 4 of them a definite diagnosis of fragile Xassociated tremor/ataxia syndrome (FXTAS) could be made, based on the proposed diagnostic criteria for FXTAS. We proposed base
## Abstract Mutations in the leucineβrich repeat kinase 2 (__LRRK2__) gene are the most common genetic determinant of Parkinson's disease (PD) in Europeanβderived populations, but far less is known about __LRRK2__ mutations and susceptibility alleles in Asians. To address this issue, we sequenced t