Low-dose cytosine arabinoside as remission induction therapy in refractory adult acute lymphocytic leukemia
β Scribed by Pall T. Onundarson; Jacob M. Rowe
- Book ID
- 115682772
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 338 KB
- Volume
- 86
- Category
- Article
- ISSN
- 1555-7162
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π SIMILAR VOLUMES
## Abstract ## BACKGROUND Drug resistance and early disease recurrence were major contributing factors in the limited survival of patients with acute lymphocytic leukemia (ALL). New chemotherapeutic agents and drug combinations were employed in refractory patients to overcome drug resistance. ##
Six adults with refractory acute lymphocytic leukemia (ALL) were treated with high-dose methotrexate, citrovorum factor, and vincristine. All patients had previously received extensive treatment with standard therapeutic agents, including vincristine, and all but one had received prior methotrexate.