Seven patients with a myelodysplastic syndrome or "smoldering" acute myelogenous leukemia were treated with cytosine arabinoside in low dosage. Four patients experienced transient, partial responses characterized by improved peripheral blood counts, cessation of transfusion requirements, and a decre
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Low-dose cytosine arabinoside (Ara-C) therapy in the myelodysplastic syndromes and acute leukemia
โ Scribed by Jane N. Winter; Daina Variakojis; Ellen R. Gaynor; Richard A. Larson; Kenneth B. Miller
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 664 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0008-543X
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Thirteen leukemic patients with disease refractory to conventional chemotherapy were treated with 1.0 to 7.5 g/m2 of Cytosine Arabinoside (Ara-C) over 29 drug cycles. Drug infusions were spaced at 12-hour intervals; a maximum of four doses was administered over 36 hours. After single dose tolerance