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Low-dose adriamycin remission maintenance for advanced acute lymphoblastic leukemia: A southwest oncology group study

✍ Scribed by Hvizdala, Eva ;Komp, Diane ;Ragab, Abdel ;Crist, William ;Chu, Jen-Yih

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
295 KB
Volume
9
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

A low‐dose maintenance schedule of adriamycin was evaluated in children with advanced acute lymphoblastic leukemia. Thirty‐six evaluable patients who achieved two or more remissions were given adriamycin, 10 mg/m^2^/week, as a single maintenance agent. The median duration of second remission was 17 weeks, but only 5 weeks for third and fourth remission. Although the therapy was not found effective in more advanced disease, the median duration of second remission approached that obtained from various multi‐agent treatment schedules. We conclude that the therapeutic efficacy of this treatment schedule makes it appealing for incorporation into multi‐drug combination regimens.

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