Adriamycin in combination chemotherapy of adult acute lymphoblastic leukemia: A southwest oncology group study
β Scribed by Shaw, Michael T. ;Raab, Spencer O.
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 350 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0098-1532
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Eighteen (72%) of 25 evaluable and previously untreated patients with adult acute lymphoblastic leukemia entered complete remission (CR) following induction therapy with Adriamycin, vincristine, and prednisone in a Southwest Oncology Group study. Remission maintenance therapy with methotrexate and 6βmercaptopurine resulted in a median duration of CR of 10.2 months. The addition of Adriamycin to prednisone and vincristine may be beneficial in slow responders or nonresponders to these two drugs and in patients with initially high peripheral blood blast counts.
π SIMILAR VOLUMES
## Abstract A lowβdose maintenance schedule of adriamycin was evaluated in children with advanced acute lymphoblastic leukemia. Thirtyβsix evaluable patients who achieved two or more remissions were given adriamycin, 10 mg/m^2^/week, as a single maintenance agent. The median duration of second remi