Loss of the Neurofibromin-NF1 Gene Product and Composite Pheochromocytoma
โ Scribed by NORIKO KIMURA; MASAYUKI FUKASE; ATSUSHI WAKITA; ITARU KIMURA
- Book ID
- 111397705
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 468 KB
- Volume
- 971
- Category
- Article
- ISSN
- 0890-6564
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Tumor suppressor genes encode proteins involved in growth regulation in differentiating and proliferating cells. Previous work from our laboratory has demonstrated that the neurofibromatosis 1 (NF1) tumor suppressor gene is dramatically upregulated in astrocytes stimulated with dibutyryl cyclic AMP
Neurofibromin, the product of the neurofibromatosis type 1 (NF1) gene, is a -250 kDa protein expressed predominantly in cortical neurons and oligodendrocytes in the central nervous system (CNS) and sensory neurons and Schwann cells in the peripheral nervous system (PNS). To gain insight into the bio