๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Allelic Loss of the NF1 Gene in NF1-Associated Plexiform Neurofibromas

โœ Scribed by Lan Kluwe; Reinhard E Friedrich; Victor F Mautner


Book ID
114136912
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
153 KB
Volume
113
Category
Article
ISSN
0165-4608

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Plexiform neurofibromas in NF1
โœ Thomas R. Welch ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 94 KB
Germline and somatic NF1 gene mutations
โœ Meena Upadhyaya; Gill Spurlock; Bisma Monem; Nick Thomas; Reinhard E. Friedrich; ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 89 KB ๐Ÿ‘ 1 views

Neurofibromatosis type 1 (NF1), a common autosomal dominant neurogenetic disorder affecting 1 in 4000 individuals worldwide, results from functional inactivation of the 17q11.2-located NF1 gene. Plexiform neurofibroma (PNF) is a congenital benign tumour present in 30-50% of NF1 patients, which in ab

NF1 mutations in neurofibromatosis 1 pat
โœ Lan Kluwe; Reinhard E. Friedrich; Bruce Korf; Raimund Fahsold; Victor-F. Mautner ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 198 KB ๐Ÿ‘ 1 views

Neurofibromatosis 1 (NF1) is an autosomal dominant disorder caused by genetic alterations of the NF1 gene on 17q11.2. About 30% of NF1 patients develop plexiform neurofibromas (PNFs), which often cause severe clinical deficits. To determine whether there is a certain genotype underlying PNFs or subt

Loss of NF1 allele in schwann cells but
โœ Lan Kluwe; Reinhard Friedrich; Victor-F. Mautner ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 86 KB

Neurofibromas, the hallmark of neurofibromatosis 1, are composed mainly of Schwann cells and fibroblasts. Inactivation of both NF1 alleles is the cause of these benign tumors, but it is unknown which cell type is the progenitor. In this study, we selectively cultured Schwann cells from an NF1-associ