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Increased expression of the neurofibromatosis 1 (NF1) gene product, neurofibromin, in astrocytes in response to cerebral ischemia

✍ Scribed by M.J. Giordano; D.K. Mahadeo; Y.Y. He; R.T. Geist; C. Hsu; D.H. Gutmann

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
813 KB
Volume
43
Category
Article
ISSN
0360-4012

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✦ Synopsis

Tumor suppressor genes encode proteins involved in growth regulation in differentiating and proliferating cells. Previous work from our laboratory has demonstrated that the neurofibromatosis 1 (NF1) tumor suppressor gene is dramatically upregulated in astrocytes stimulated with dibutyryl cyclic AMP and proinflammatory cytokines. To explore the possibility that the NFZ gene product, neurofibromin, plays a role in the reactive gliosis seen in response to cerebral ischemia, expression of N F l was examined in both focal and global models of rat cerebral ischemia. In this report, we demonstrate the increased expression of both neurofibromin and glial fibrillary acidic protein (GFAP) in astrocytes surrounding areas of focal ischemia. Similar increases in neurofibromin and GFAP immunoreactivity were also observed in reactive astrocytes in the hippocampal region in a global model of ischemia. These results suggest a novel role for the N F l tumor suppressor gene in growth regulatory pathways involved in cellular remodeling and in response to injury.

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