Recent studies have suggested that abnormalities in the adenomatous polyposis coli gene (AP C gene) are associated with the development not only of familial adenomatous polyposis coli (FAP) but also of cancers in digestive organs. In order to elucidate whether abnormalities of the APC gene could con
Loss of the adenomatous polyposis coli gene and human papillomavirus infection in oral carcinogenesis
β Scribed by Er-Jia Mao; D. Oda; W.G. Haigh; A.M. Beckmann
- Book ID
- 116169203
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 558 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0964-1955
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm
Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia. Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma o