## Abstract RB protein expression and loss of heterozygosity (LOH) in the RB gene were studied in 77 primary lung carcinomas of all histological types. RB protein expression was studied by immunohistochemistry with 3 antiβRB antibodies, and was found altered in 23/29 (79%) neuroβendocrine (NE) carc
Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression
β Scribed by Hong-Ji Xu; Paul Cairns; Shi-Xue Hu; Margaret A. Knowles; William F. Benedict
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- French
- Weight
- 533 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The significance of loss of heterozygosity (LOH) of chromosome 9 as an early event in human bladder tumors has been demonstrated by several studies. We have studied LOH of the ABO gene locus at 9q34.2 by means of polymerase chain reaction (PCR) genotyping of tumor preparations and leuko
Loss of heterozygosity (LOH) affecting loci at I I p I 3 and I I p I 5 occurs in childhood and adult carcinomas, including non-small cell lung cancer (NSCLC). In NSCLC, the highest reported frequency of LOH was 72% at the I I p I 3 catalase (CAT) locus. As this locus is centromeric t o the Wilms' tu
## Abstract Recent studies have shown that intraductal prostate carcinoma (IDCβP) should be considered as a separate lesion distinct from prostatic intraepithelial neoplasia (PIN). The purpose of the present study was to analyze the genetic relationship between benign prostatic tissue, PIN, invasiv