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Correlation of loss of heterozygosity at 11 p with tumour progression and survival in non-small cell lung cancer

✍ Scribed by Kwun M. Fong; Paul V. Zimmerman; Peter J. Smith

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 523 KB
Volume: 10
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870100306

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✦ Synopsis

Loss of heterozygosity (LOH) affecting loci at I I p I 3 and I I p I 5 occurs in childhood and adult carcinomas, including non-small cell lung cancer (NSCLC). In NSCLC, the highest reported frequency of LOH was 72% at the I I p I 3 catalase (CAT) locus. As this locus is centromeric t o the Wilms' tumour (WTI) locus, possible involvement of WTI in the pathogenesis of NSCLC was considered. We thus examined I0 I cases of NSCLC for LOH at the WTI and five other polymorphic loci along I I p. A t I I p 13, the frequencies of LOH were 20% (9146) at the FSHB locus, 9% (5153) at the WTI locus, and 15% (6/41) at the CAT locus. The shortest region of overlap (SRO) at I I p I 3 was mapped centromeric to, but excluding, the WTI locus. Only adenocarcinomas showed LOH in this region. A t I I p 15, LOH affected 23% (I 8/77) of informative cases, with the highest frequency of 36% at the insulin (INS) locus. The SRO at I I p I 5 was mapped telomeric t o the RRM I locus. A third region, at I I p I 3-I 5 between WTI and R R M I , was also affected by LOH. LOH at I I p correlated significantly with advanced T stage and nodal involvement in NSCLC tumours. In the squamous cell carcinoma subtype, LOH along I I p also correlated with nodal involvement. Furthermore, squamous tumours with LOH involving I I p I 3 loci had significantly worse survival than those without LOH. These data suggest that tumor suppressor gene(s) on I I p affect the progression of NSCLC, particularly squamous cell carcinomas. Genes Chromosom Cancer 10: 1831189 (I 994).

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