Cells with abnormal TP53 lose cell cycle checkpoints, resulting in genomic instability and neoplastic transformation. However, the evidence linking the tumor-specific targets of genomic alteration to an abnormal TP53 is limited. The present study tested the hypothesis that TP53 abnormalities are cor
โฆ LIBER โฆ
Immunohistochemical expression of BRCA2 protein and allelic loss at the BRCA2 locus in prostate cancer
โ Scribed by Stephen M. Edwards; William D. Dunsmuir; Cheryl E. Gillett; Sunil R. Lakhani; Catherine Corbishley; Martin Young; Roger S. Kirby; David P. Dearnaley; Anna Dowe; Audrey Ardern-Jones; Jo Kelly; CRC/BPG UK Fmilial Prostate Cancer Study Collaborators; Nigel Spurr; Diana M. Barnes; Rosalind A. Eeles
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- French
- Weight
- 370 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0020-7136
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We have examined the role of the breast cancer susceptibility genes BRCA1 and BRCA2 and other loci in the vicinity of these 2 genes on the long arms of chromosomes 17 and 13 (17q and 13q) for the presence of genomic deletions in breast cancer among Taiwanese women. Breast cancer in Taiwan is particu