𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Loss of normal allele of the APC gene in an adrenocortical carcinoma from a patient with familial adenomatous polyposis

✍ Scribed by Madoka Seki; Kiyoko Tanaka; Rei Kikuchi-Yanoshita; Motoko Konishi; Hiroyuki Fukunari; Takeo Iwama; Michiko Miyaki

Publisher
Springer
Year
1992
Tongue
English
Weight
272 KB
Volume
89
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

✦ Synopsis

Endocrine neoplasms have been reported occasionally in patients with familial adenomatous polyposis (FAP). An adrenocorotical carcinoma was studied in a patient with a family history of FAP. Loss of heterozygosity (LOH) in the region close to the adenomatous polyposis coli (APC) gene was detected in this carcinoma, and evidence was obtained that there was a loss of the normal allele of the APC gene. This is the first demonstration of LOH at the APC locus in adrenocortical tumors. The present results and our previous data on LOH in a recurring desmoid tumor suggest that the heterozygous mutant/wild-type condition of the APC gene may give rise to benign tumors, and that functional loss of this gene leads to development of tumors not only in the colon but also in other various parts of the body in FAP patients.

πŸ“œ SIMILAR VOLUMES

Mutation analysis of the adenomatous pol
Mutation analysis of the adenomatous polyposis coli (APC) gene in Danish patients with familial adenomatous polyposis (FAP)
✍ Marie Luise Bisgaard; RASMUS S. Ripa; Steffen BΓΌlow πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 26 KB πŸ‘ 2 views

## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm

Mutation analysis of the adenomatous pol
Mutation analysis of the adenomatous polyposis coli (APC) gene in northwest Spanish patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer
✍ Clara Ruiz-Ponte; Ana Vega; Angel Carracedo; Francisco Barros πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 26 KB πŸ‘ 2 views

Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T

Interstitial loss of the same region of
Interstitial loss of the same region of 5q in multiple adenomas and a carcinoma derived from an adenomatous polyposis coli (apc) patient
✍ Yoshio Miki; Isamu Nishisho; Yusuke Nakamura; Yasuo Miyoshi; Joji Utsunomiya πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 341 KB πŸ‘ 2 views

## Abstract Accumulation of genetic alterations in oncogenes and tumor suppressor genes causes the transformation of a normal cell into a malignant cell. Recently, Fearon and Vogelstein (Cell 61:759‐767, 1990) reported on a model for the genetic pathway in development of colorectal neoplasia. To in

K-ras mutation and loss of heterozygosit
K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma
✍ N. Peter Zauber; Marlene Sabbath-Solitare; Stephen P. Marotta; D. Timothy Bishop πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 151 KB πŸ‘ 2 views

## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit