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Loss of Heterozygosity on Chromosome 9 and Loss of Chromosome 9 Copy Number are Separate Events in the Pathogenesis of Transitional Cell Carcinoma of the Bladder

โœ Scribed by Van Tilborg, A.A.G.; Hekman, A.C.P.; Vissers, K.J.; van der Kwast, T.H.; Zwarthoff, E.C.

Book ID
122612758
Publisher
Lippincott Williams and Wilkins
Year
1998
Tongue
English
Weight
128 KB
Volume
160
Category
Article
ISSN
0022-5347

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Loss of heterozygosity on chromosome 9 a
Loss of heterozygosity on chromosome 9 and loss of chromosome 9 copy number are separate events in the pathogenesis of transitional cell carcinoma of the bladder
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The most frequent genetic aberration found in transitional cell carcinoma (TCC) of the bladder involves chromosome 9. Loss of heterozygosity (LOH) analyses show deletions of both chromosome 9p and 9q, while in situ hybridization studies suggest a significant percentage of tumours with monosomy 9. To

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Loss of heterozygosity at chromosome segments 8p22 and 8p11.2-21.1 in transitional-cell carcinoma of the urinary bladder
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To identify the putative tumor-suppressor gene (TSG) involved in transitional-cell carcinoma (TCC) of the urinary bladder, we undertook an allelotyping analysis in 48 cases of TCC. Relatively high percentages of allelic loss were found in 2p (5 of 23, 21.7%), 8p (9 of 21, 42.9%), 9p (4 of 20, 20.0%)