Is Chromosome 9 Loss a Marker of Disease Recurrence in Transitional Cell Carcinoma of the Urinary Bladder?
β Scribed by Bartlett, J.M.S.; Watters, A.D.; Ballantyne, S.A.; Going, J.J.; Grigor, K.M.; Cooke, T.G.
- Book ID
- 122390591
- Publisher
- Lippincott Williams and Wilkins
- Year
- 1999
- Tongue
- English
- Weight
- 124 KB
- Volume
- 161
- Category
- Article
- ISSN
- 0022-5347
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The most frequent genetic aberration found in transitional cell carcinoma (TCC) of the bladder involves chromosome 9. Loss of heterozygosity (LOH) analyses show deletions of both chromosome 9p and 9q, while in situ hybridization studies suggest a significant percentage of tumours with monosomy 9. To
To identify the putative tumor-suppressor gene (TSG) involved in transitional-cell carcinoma (TCC) of the urinary bladder, we undertook an allelotyping analysis in 48 cases of TCC. Relatively high percentages of allelic loss were found in 2p (5 of 23, 21.7%), 8p (9 of 21, 42.9%), 9p (4 of 20, 20.0%)