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Loss of heterozygosity (LOH) in 15q26.2→ter in breast cancer

✍ Scribed by Gerardo Páez; Silvina Richard; Martha S. Bianchi; Néstor O. Bianchi

Book ID
114070515
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
42 KB
Volume
484
Category
Article
ISSN
0027-5107

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One of the main genetic abnormalities associated with breast carcinogenesis is the loss of genetic material from chromosome arm 16q. Different groups have identified two regions (16q22.1 and 16q24-ter) that are frequently deleted in primary tumors, suggesting the presence of tumor suppressor genes i