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Loss of heterozygosity in the HLA class I region in human pancreatic cancer

✍ Scribed by E. Ryschich; O. Cebotari; O.V. Fabian; F. Autschbach; J. Kleeff; H. Friess; A. Bierhaus; M.W. Büchler; J. Schmidt


Book ID
110892053
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
546 KB
Volume
64
Category
Article
ISSN
0001-2815

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Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeu