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Distribution of HLA class I altered phenotypes in colorectal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21

✍ Scribed by Isabel Maleno; Carmen Maria Cabrera; Teresa Cabrera; Laura Paco; Miguel Angel López-Nevot; Antonia Collado; Antonio Ferrón; Federico Garrido

Book ID
105947531
Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
229 KB
Volume
56
Category
Article
ISSN
0093-7711

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## Abstract HLA class I loss or downregulation is a widespread mechanism used by tumor cells to avoid tumor recognition by cytotoxic T lymphocytes favoring tumor immune escape. Multiple molecular mechanisms are responsible for these altered HLA class I tumor phenotypes. It has been described in dif