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Multiple mechanisms generate HLA class I altered phenotypes in laryngeal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21

✍ Scribed by Isabel Maleno; Miguel López-Nevot; Teresa Cabrera; José Salinero; Federico Garrido

Book ID: 105966555
Publisher: Springer-Verlag
Year: 2002
Tongue: English
Weight: 340 KB
Volume: 51
Category: Article
ISSN: 0340-7004
DOI: 10.1007/s00262-002-0296-0

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## Abstract HLA class I loss or downregulation is a widespread mechanism used by tumor cells to avoid tumor recognition by cytotoxic T lymphocytes favoring tumor immune escape. Multiple molecular mechanisms are responsible for these altered HLA class I tumor phenotypes. It has been described in dif