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Loss of heterozygosity from the short arm of chromosome 8 is associated with invasive behavior in breast cancer

✍ Scribed by M. Lisa Yaremko; Chris Kutza; Judy Lyzak; Rosemarie Mick; Wendy M. Recant; Carol A. Westbrook

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 603 KB
Volume: 16
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199607)16:3<189::aid-gcc6>3.0.co;2-v

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✦ Synopsis

Loss of heterozygosity (LOH) from the short arm of chromosome 8 (8p) is frequent in many human cancers, including breast, colon, prostate. and bladder cancers. LOH occurs in two regions of 8p, 8p2I and 8p22, and suggests the presence of two separate tumor suppressor genes. In breaa cancers, 8p LOH OCCUK in both early and late clinical stage tumors, while in colon, prostate, and bladder cancers, there is an association between 8p LOH and advanced clinical stage. We investigated this discrepancy by comparing 8p LOH in infiltrating ductal carcinomas (IDC) t o breast cancers of earlier clinical stage, i .e., tumors with no invasion [ductal carcinoma in situ (DCIS)only tumors]. We used three markers which sample several reported loci of 8p LOH. We microdissected tumor from paraffi n blocks of 39 IDC and 23 DCIS-only breast cancers and amplified tumorhormal DNA pairs for the microsatellite markers D8S254 (8p22), D8S133 (8pZl.3), and NEFL (8~21). All cases of IDC were informative with at least one marker, with a combined rate of LOH of 46%. The results for each marker were [no. LOWno. informative (%)I: D8S254, 8/26 (31 %); D8S I33 I2/3 I (39%), and NEFL, 9/25 (36%). In the DClSonly group, all 23 were informative for at least one marker, but 8p LOH was absent. We conclude that 8p LOH from 8p2 1-22 is frequent in IDC of the breast, but absent in DCIS-only cases, and may play a role in breast cancer progression by conferring invasive ability. Genes

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