Ring chromosome 12 resulting from nonrandom telomeric associations with the short arm of chromosome 15 in a cerebellar astrocytoma
✍ Scribed by Jeffrey R. Sawyer; Gael Sammartino; M. Husain; Jane M. Lewis; Bruce Anderson; Frederick A. Boop
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 384 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
Ring chromosome I2 was found in an untreated cerebellar astrocytoma apparently resulting from nonrandom telomeric associations involving the short arm of chromosome IS, and both the long and short arms of chromosome 12. The clonal nonrandom telomeric associations of I5p to both ends of the chromosome I 2 were transitory, but appear to be the precursor lesion in the evolution to ring chromosome I 2 in this tumor. A multistep process in the formation of a ring chromosome resulting from nonrandom telomeric associations to both telomeres is illustrated. Genes Chrom Cancer 8:69-73 ( I 993).