Forty-eight samples of primary non-small-cell lung cancer (NSCLC) and normal tissue from the same patients were analyzed for allelic deletions on chromosome I I p. Five polymorphic loci were assessed to determine the incidence of I Ip sequence deletions and to define hot-spots of deletions. Informat
Loss of genes on the short arm of chromosome 11 in bladder cancer
β Scribed by Fearon, Eric R.; Feinberg, Andrew P.; Hamilton, Stanley H.; Vogelstein, Bert
- Book ID
- 109741987
- Publisher
- Nature Publishing Group
- Year
- 1985
- Tongue
- English
- Weight
- 479 KB
- Volume
- 318
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/318377a0
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## Loss of heterozygosity (LOH) on chromosomes 3p and 9p has been documented in a variety of malignancies, which suggests the presence of tumor suppressor gene loci on these chromosomes. We have studied 77 oral carcinomas for LOH using 16 microsatellite markers distributed over 5 human chromosomes.
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