Cytogenetic and RFLP studies have shown that chromosome I0 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in tumorigenesis is present on this chromosome. Forty-one tumors were examined for loss of heterozygosity at 23 loci on chromosome 10 to determ
Loss of constitutional heterozygosity for loci on chromosome 6q in human malignant melanoma
β Scribed by DM Millikin; CM Witkowski; EU Meese; JM Trent
- Book ID
- 119105061
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 59 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0165-4608
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Gene deletion of chromosome 10 in 11 tumor tissues removed from nine patients with malignant glioma (seven glioblastomas and two malignant astrocytomas) was investigated. Loss of heterozygosity was found in four of the seven (57%) cases with glioblastoma, whereas heterozygosity was preserved in two
Forty-four breast carcinomas were studied for loss of heterozygosity (LOH) at 25 microsatellite markers distributed almost evenly along chromosome arm 22q. LOH at at least one marker were observed in 66% tumors, while 6 regions of consistent LOH were identified. The size of each region ranged betwee