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Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma

✍ Scribed by Hertel, Christina B; Zhou, Xiao-ge; Hamilton-Dutoit, Stephen J; Junker, Steffen

Book ID
110066806
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
529 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract Hodgkin and Reed‐Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) show genotypic features of germinal centre‐derived B‐cells in most cases. Nevertheless, these cells typically lack expression of B‐cell antigens. Previous studies have suggested that plasma cell differentiation m