The zygosity of 19 colorectal carcinomas (either near-diploid or polyploid) from patients known to be heterozygous for RFLPs located on chromosome 18 or on the short arm of chromosome 17 has been examined. In most cases, at least one allele was significantly under-represented. The reason for the abs
Loss of alleles on the short arm of chromosome 11 in a hepatoblastoma from a child with Beckwith-Wiedemann syndrome
โ Scribed by Melissa H. Little; Damien B. Thomson; Nicholas K. Hayward; Peter J. Smith
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 731 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0340-6717
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Loss of heterozygosity (LOH) from the short arm of chromosome 8 (8p) is frequent in many human cancers, including breast, colon, prostate. and bladder cancers. LOH occurs in two regions of 8p, 8p2I and 8p22, and suggests the presence of two separate tumor suppressor genes. In breaa cancers, 8p LOH O