Lopinavir/ritonavir population pharmacokinetics in neonates and infants
✍ Scribed by Saik Urien; Ghislaine Firtion; Suzanne T. Anderson; Deborah Hirt; Caroline Solas; Gilles Peytavin; Albert Faye; Isabelle Thuret; Marthe Leprevost; Carole Giraud; Hermione Lyall; Saye Khoo; Stéphane Blanche; Jean-Marc Tréluyer
- Book ID
- 108642712
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 706 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0306-5251
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In this study, we explored the bioavailability in dogs and chemical potency of generic ritonavir and lopinavir/ritonavir tablet products manufactured by various pharmaceutical companies. Chemical potency of the products was examined by HPLC quantitation of ritonavir and lopinavir. Using a dog model,
We would like to respond to the two Letters to the Editor that have been submitted in response to our manuscript reporting on the relative bioavailability of generic ritonavir and lopinavir/ritonavir tablet products in dogs. Both Letters criticize the dog model used in our studies, suggesting that