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Long-term safety of dichloroacetate in congenital lactic acidosis

✍ Scribed by Abdelmalak, Monica; Lew, Alicia; Ramezani, Ryan; Shroads, Albert L.; Coats, Bonnie S.; Langaee, Taimour; Shankar, Meena N.; Neiberger, Richard E.; Subramony, S.H.; Stacpoole, Peter W.

Book ID: 123345688
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 270 KB
Volume: 109
Category: Article
ISSN: 1096-7192
DOI: 10.1016/j.ymgme.2013.03.019

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Sir: Dichloroacetate (DCA, 15-20 mg/kg per day) was given orally twice daily to a 12-mouth-old boy with congenital lactic acidosis [1,3]. The clinical and laboratory findings were compatible with Leigh syndrome [2]. Enzyme activities associated with lactate metabolism were normal in his fibroblasts