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Long-term safety of dichloroacetate in congenital lactic acidosis

✍ Scribed by Monica Abdelmalak; Alicia Lew; Ryan Ramezani; Albert L. Shroads; Bonnie S. Coats; Meena N. Shankar; Peter W. Stacpoole

Book ID: 119326988
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 60 KB
Volume: 12
Category: Article
ISSN: 1567-7249
DOI: 10.1016/j.mito.2012.07.019

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Sir: Dichloroacetate (DCA, 15-20 mg/kg per day) was given orally twice daily to a 12-mouth-old boy with congenital lactic acidosis [1,3]. The clinical and laboratory findings were compatible with Leigh syndrome [2]. Enzyme activities associated with lactate metabolism were normal in his fibroblasts