Dichloroacetate in the treatment of congenital lactic acidosis
✍ Scribed by A. Aynsley-Green; A. M. Weindling; G. Soltész; B. Ross; P. A. Jenkins
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 142 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0141-8955
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📜 SIMILAR VOLUMES
Sir: Dichloroacetate (DCA, 15-20 mg/kg per day) was given orally twice daily to a 12-mouth-old boy with congenital lactic acidosis [1,3]. The clinical and laboratory findings were compatible with Leigh syndrome [2]. Enzyme activities associated with lactate metabolism were normal in his fibroblasts
## Abstract ## BACKGROUND: Lactic acidosis (LA) is common in hospitalized patients and is associated with poor clinical outcomes. There have been major recent advances in our understanding of lactate generation and physiology. However, treatment of LA is an area of controversy and uncertainty, and
## ABSTRACTS time from the venipuncture until availability of serum drug level was 2.13 +\_ 0.88 hours in Group 1 and 0.45 \_+\_+ 0.35 hours in Group 2 (P < .001). Based on initial pulse, respiratory rate, and the physician's estimate of respiratory distress, Group 2 patients were somewhat more il