✦ LIBER ✦

Long-term carcinogenicity and toxicity studies of patulin in the rat

✍ Scribed by Peter J. Becci; Frederick G. Hess; William D. Johnson; Michael A. Gallo; John G. Babish; Robert E. Dailey; Richard A. Parent

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 514 KB
Volume: 1
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550010504

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Patulin is a mycotoxin produced by a variety of Penicillium and Aspergillus species which are likely natural contaminants of various foods. The present study was conducted to determine the effects of lifetime administration of patulin in FDRL Wistar rats. Animals received patulin by gastric intubation three times per week at the level of 0.0, 0.1, 0.5 and 1.5 mg per kg body weight. The animals used in this lifetime study were derived from F~0~ parents exposed to equivalent levels of patulin for 4 weeks before mating, and throughout mating, gestation and lactation. Patulin treatment at 0.5 and 1.5 mg kg^−1^ to male rats caused a significant decrease in body weight gain in comparison to controls. Body weights of treated female rats were similar to that of control rats. No consistent significant differences among groups were noted in the hematology, clinical chemistry or urine analysis parameters measured during or at the termination of the study. Patulin administered to male and female rats at 1.5 mg kg^−1^ caused a significantly increased mortality rate as compared to respective control animals. The cause of death appeared to be increased pulmonary and laryngotracheal inflammation. No tumorigenic effect of patulin was observed.

📜 SIMILAR VOLUMES

Long-term carcinogenicity and toxicity s

Long-term carcinogenicity and toxicity study of zearalenone in the rat

✍ Peter J. Becci; Kenneth A. Voss; Frederick G. Hess; Michael A. Gallo; Richard A. 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 870 KB

## Abstract The effects of lifetime dietary administration of zearalenone, a fungal estrogen produced by __Fusarium__ spp., were studied in FDRL Wistar rats. Animals were fed a control diet or a diet supplemented with zearalenone at levels of 0.1, 1.0 or 3.0 mg per kg body weight per day. The anima

Two-year toxicity and carcinogenicity st

Two-year toxicity and carcinogenicity study of acrolein in rats

✍ Richard A. Parent; Halina E. Caravello; James E. Long 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 849 KB

Five-hundred and sixty Sprague-Dawley rats were randomized into one control and three treatment groups (70 of each sex per group). Animals were treated by daily gavage with 0.0, 0.05, 0.5 and 2.5 mg kg-' acrolein in water (10 ml kg-I). These dosing levels were selected as a result of a 6-week range-

Short-term toxicity studies of vanadium

Short-term toxicity studies of vanadium in rats

✍ J. L. Domingo; J. M. Llobet; J. M. Tomas; J. Corbella 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB

Vanadium (in the form of NaV03) was given in drinking water to groups of 10 male Sprague-Dawley rats over a period of 3 months at concentrations of 0, 5 , 10 and 50ppm. Vanadium accumulated dosedependently in the kidneys and spleen. Appearance, behaviour, food and water consumption, growth and morta

Long-term carcinogenicity of pan masala

Long-term carcinogenicity of pan masala in Swiss mice

✍ Rajani A. Bhisey; Asha G. Ramchandani; Antony V. D'Souza; Anita M. Borges; Perin 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 290 KB 👁 1 views

Carcinogenicity of pan masala, a dry powdered chewing mixture of areca nut, catechu, lime, spices and flavoring agents was evaluated by means of the long-term animal bio-assay 6-to 7-week old male and female S/RVCri mice were divided randomly into intermediate and lifetime exposure groups and fed no

Short-term toxicity study of allyl isoth

Short-term toxicity study of allyl isothiocyanate in rats

✍ Lewerenz, H.-J. ;Plass, R. ;Bleyl, D. W. R. ;Macholz, R. 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 308 KB

Allyl isothiocyanate (AITC) was given in doses of 0, 10, 20, or 40 mg/kg (5 days/week) by oral intubation to male rats for up to 6 weeks. The highest dosage level caused a decrease in body weight, thymus weight, blood glucose and serum globulin levels. Haematological examination revealed an increase

Carcinogenicity of phenacetin: Long-term

Carcinogenicity of phenacetin: Long-term feeding study in B6C3F1 mice

✍ Keisuke Nakanishi; Yasushi Kurata; Masato Oshima; Shoji Fukushima; Nobuyuki Ito 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 927 KB

## Abstract Groups of 52 B6C3F~1~ mice of each sex were maintained on a diet containing 1.25 or 0.6% phenacetin for 96 weeks and then fed a basal diet for 8 weeks. Control groups consisted of 50 mice of each sex and were fed a basal diet for 104 weeks. All animals were killed at the end of the expe