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Long-lasting effects of chronic ethanol administration on the activity of antioxidant enzymes

✍ Scribed by Almeida, V??nia D' ;Monteiro, Maristela Goldnadel ;Oliveira, Maria Gabriela M. ;Pomarico, Ana Cristina ;Bueno, Orlando Francisco Amodeo ;da Silva-Fernandes, Maria Eugěnia

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
218 KB
Volume
9
Category
Article
ISSN
0887-2082

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✦ Synopsis

The aim of this study was to investigate the long-lasting effects of prolonged administration of ethanol doses on oxidative processes of aged rats. We determined the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in erythrocytes of rats 15, 20, and 24 months old treated with an average daily dose of 1.5 g/Kg of ethanol or saline administered intraperitoneally for 13 weeks and after a 2 month period of withdrawal from treatment. The activity of all three enzymes decreased significantly with aging in the controls, while no age-related changes were found among treated rats. These findings are important since they are the first to show a longlasting toxic effect of low ethanol doses observed in association with the aging process.

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