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Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

✍ Scribed by Frackelton, Edward C; Annaiah, Kiran; Kugathasan, Subra; Baldassano, Robert N; Bradfield, Jonathan P; Sleiman, Patrick M A; Imielinski, Marcin; Guthery, Stephen L; Cucchiara, Salvatore; Kim, Cecilia E


Book ID
109914297
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
421 KB
Volume
40
Category
Article
ISSN
1061-4036

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Filaggrin loss-of-function variants are
✍ J. Van Limbergen; R.K. Russell; E.R. Nimmo; Y. Zhao; H. Liao; H.E. Drummond; G. πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 100 KB

Background: Pediatric inflammatory bowel disease (IBD) has a high prevalence of coexistent atopy. Filaggrin (FLG) loss-of-function variants (null-alleles) are associated with eczema and asthma in association with eczema. The aim was to assess the contribution of FLG null-alleles to pediatric IBD sus