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Investigation of Reported Associations Between the 20q13 and 21q22 Loci and Pediatric-Onset Crohn's Disease in Canadian Children

✍ Scribed by Amre, Devendra K; Mack, David R; Morgan, Kenneth; Fujiwara, Mary; Israel, David; Deslandres, Colette; Seidman, Ernest G; Lambrette, Phlippe; Costea, Irina; Krupoves, Alfreda; Fegury, Houda; Dong, Jinsong; Grimard, Guy; Levy, Emile


Book ID
126903963
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
116 KB
Volume
104
Category
Article
ISSN
0002-9270

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Investigation of associations between th
✍ Devendra K. Amre; David R. Mack; David Israel; Kenneth Morgan; Alfreda Krupoves; πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 86 KB πŸ‘ 2 views

## Background: The pregnane-X-receptor (PXR) is involved in the metabolism and detoxification of numerous xenobiotics and is critical for maintaining intestinal integrity. The NR1I2 gene encoding PXR may confer susceptibility for Crohn's disease (CD) but evidence for associations is conflicting. We