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Localization of transfected B7-1 (CD80) DNA in human melanoma cells after particle-mediated gene transfer

โœ Scribed by Donna O. McCarthy; Lorraine F. Meisner; Jeanne Bourdeau-Heller; Timothy R. Roberts; Shi-Qi Wu; Thomas F. Warner; Mark R. Albertini


Book ID
114135586
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
184 KB
Volume
144
Category
Article
ISSN
0165-4608

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The present study demonstrates that the transfection of B7-I or its variant MB7-2 genes into MHC class I+ tumor cells (B 16-BL6 or K I 735-M2 melanoma) resulted in the remarkable reduction of lung metastasis caused by i.v. injection into immunocompetent syngeneic mice. However, i.v. injection of the