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Vaccination of tumor cells transfected with the B7-1 (CD80) gene induces the anti-metastatic effect and tumor immunity in mice

✍ Scribed by Hideki Fujii; Manabu Inobe; Fuminari Kimura; Jun Murata; Masaaki Murakami; Yasuharu Onishi; Ichiro Azuma; Toshimitsu Uede; Ikuo Saiki

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 766 KB
Volume: 66
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19960410)66:2<219::aid-ijc14>3.0.co;2-7

No coin nor oath required. For personal study only.

✦ Synopsis

The present study demonstrates that the transfection of B7-I or its variant MB7-2 genes into MHC class I+ tumor cells (B 16-BL6 or K I 735-M2 melanoma) resulted in the remarkable reduction of lung metastasis caused by i.v. injection into immunocompetent syngeneic mice. However, i.v. injection of the transfectants into T cell-deficient nude mice did not affect reduction of lung tumor colonies as compared with parental wild-type tumors, suggesting that such an inhibitory effect was closely associated with T cell-mediated responses. The reduced

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