## Abstract Isolated mental retardation is clinically and genetically heterogenous and may be inherited in an autosomal dominant, autosomal recessive, or Xβlinked manner. We report here a linkage analysis in a large family including 15 members, 6 of whom presenting Xβlinked nonβsyndromic mental ret
Localization of the gene for X-linked nephrogenic diabetes insipidus to Xq28
β Scribed by Kambouris, Marios ;Dlouhy, Stephen R. ;Trofatter, James A. ;Conneally, P. Michael ;Hodes, M. E. ;Optiz, John M. ;Reynolds, James F.
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 376 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0148-7299
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W e report on a family in which nonsyndromal mild to moderate mental retardation segregates as an X-linked trait (MRX41). T w o point linkage analysis demonstrated linkage between the disorder and marker DXS3 in Xq21.33 with a lod score of 2.56 at 0 = 0.0 and marker DXSllO8 in Xq28 with a lod score
Nonspecific X-linked mental retardation is a heterogeneous condition consisting of nonsyndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 i
A large family with non-specific X-linked mental retardation (MRX) was first described in 1991 [Glass et al., 19911, with a suggestion of linkage to Xq26-27. The maximum lod score was 1.60 (0 = 0.10) with the F9 locus. The localisation of this MRX gene has now been established by linkage to microsat
Three boys from two families were identified as having a syndrome of X-linked mental retardation (XLMR) with microcephaly and short stature, clinically resembling Renpenning syndrome but with normal size of testicles in affected men. When the effort to map the gene for the above condition was initia