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A gene for nonspecific X-linked mental retardation (MRX41) is located in the distal segment of Xq28

✍ Scribed by Hamel, Ben C. J.; Kremer, Hannie; Swaay, Eveline Wesby-van; van den Helm, Bellinda; Smits, Arie P. T.; Oostra, Ben A.; Ropers, Hans-Hilger; Mariman, Edwin C. M.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
26 KB
Volume
64
Category
Article
ISSN
0148-7299

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✦ Synopsis

W e report on a family in which nonsyndromal mild to moderate mental retardation segregates as an X-linked trait (MRX41). T w o point linkage analysis demonstrated linkage between the disorder and marker DXS3 in Xq21.33 with a lod score of 2.56 at 0 = 0.0 and marker DXSllO8 in Xq28 with a lod score of 3.82 at 0 = 0.0. Multipoint linkage analysis showed that the odds for a location of the gene in Xq28 vs Xq21.33 are 1OO:l. This is the fourth family with nonspecific X-linked mental retardation with Xq28-qter as the most likely gene localization.

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