Genetic localisation of MRX27 to Xq24-26 defines another discrete gene for non-specific X-linked mental retardation

✍ Scribed by Gedeon, A. K.; Glass, I. A.; Connor, J. M.; Mulley, J. C.

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 28 KB
• Volume: 64
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/(sici)1096-8628(19960712)64:1<121::aid-ajmg20>3.0.co;2-o

✦ Synopsis

A large family with non-specific X-linked mental retardation (MRX) was first described in 1991 [Glass et al., 19911, with a suggestion of linkage to Xq26-27. The maximum lod score was 1.60 (0 = 0.10) with the F9 locus. The localisation of this MRX gene has now been established by linkage to microsatellite markers. Peak pairwise lod scores of 4.02 and 4.01 (0 = 0.00) were attained at the D X S l l l 4 and DXS994 loci respectively. This MRX gene is now designated MRX27 and is localised to Xq24-26 by recombination events detected by DXS424 and DXS102. This regional localisation spans 26.2 cM on the genetic background map and defines another distinct MRX interval by linkage to a specific region of the X chromo-Some.